Twin Studies on Urinary Pepsinogen A Phenotypes and Serum Pepsinogen A Levels

Estimation of serum pepsinogen.

Pepsinogen Levels Compared with Photofluorography

Chronic atrophic gastritis, which is thought to be a high risk for gastric cancer, can be diagnosed by serum pepsinogen levels. We compared the usefulness of the measurement of pepsinogen levels and indirect photofluorography as indicators of gastric cancer in a mass screening involving 5,620 Japanese subjects (mean age: 60.1 years old; male : female = 2,268 : 3,352) in 1991 and 1992. Subjects ...

Immunological Studies on Pepsin and Pepsinogen

1. Alkali (pH 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. Similarly treated pepsins from the rabbit, chicken, and shark do not. 2. Pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. Pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, n...

Studies on the dynamics of pepsinogen distribution.

Distribution of materials (such as enzymes) between the alimentary canal and the blood stream is a complex process involving the factors of synthesis, movement into one or more compartments, and destruction.' An initial attempt to quantitate these events is presented. A theory and methodology are developed and illustrated by preliminary data on the distribution of pepsinogen. The general approa...

Radioimmunoassay of human pepsinogen A and pepsinogen C.

We describe the development of radioimmunoassays to measure both human pepsinogen A and pepsinogen C concentrations in serum. The antibodies were raised in goats by immunization with purified pepsinogen A or C. The affinity constants of the respective antibodies were 20.10(10) l/mol and 7.10(10) l/mol. Pepsinogens A and C were labeled with Na 125I by the chloramine T method. The binding between...